In a TikTok video, she said she had a body that is "paid such close attention to", so "wanted to address" concerns.
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It comes after some users commented on her apparent recent weight loss.
Grande said they were "comparing my current body" to "the unhealthiest version of my body".
“The 29-year-old US star explained: "I was on a lot of antidepressants and drinking on them and eating poorly and at the lowest point of my life when I looked the way you consider my healthy, but that in fact wasn't my healthy..”